Paternal Programming of Liver Function and Lipid Profile Induced by a Paternal Pre-Conceptional Unhealthy Diet: Potential Association with Altered Gut Microbiome Composition
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چکیده
منابع مشابه
Paternal Allele Influences High Fat Diet-Induced Obesity
C57BL/6J (B6) mice are susceptible to high-fat diet (HFD)-induced obesity and have been used in metabolism research for many decades. However, the genetic component of HFD-induced obesity has not yet been elucidated. This study reports evidence for a paternal transmission of HFD-induced obesity and a correlated expression of Igf2 and Peg3 (paternal expressed gene 3) imprinted genes. We found th...
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Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder in the world, yet the pathogenesis of the disease is not well elucidated. Due to the close anatomic and functional association between the intestinal lumen and the liver through the portal system, it is speculated that the gut microbiome may play a pivotal role in the pathogenesis of NAFLD. Furthermore, diet, which can m...
متن کاملA paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice.
Dietary intake of methyl donors, such as folic acid and methionine, shows considerable intra-individual variation in human populations. While it is recognized that maternal departures from the optimum of dietary methyl donor intake can increase the risk for mental health issues and neurological disorders in offspring, it has not been explored whether paternal dietary methyl donor intake influen...
متن کاملLipid profile with paternal history of coronary heart disease before age 40.
Serum lipids were measured in children and their parents from 40 families in which the father had a myocardial infarction or coronary heart disease (CHD) before age 40 years. The relationship between physical activity and serum lipid concentrations in the children was also evaluated. Twenty six men had one or more abnormal lipid value (in mmol/l): total venous cholesterol (TVC) > 6.24, triglyce...
متن کاملPaternal Postpartum Depression and Its Relationship With Maternal Postpartum Depression
Introduction: Evidence shows that some men suffer from Postpartum Depression (PPD), and that the adverse effects of this unknown phenomenon affect them and their family. Objective: The purpose of this study was to determine paternal PPD and its relationship with some factors, especially maternal PPD. Materials and Methods: This cross-sectional study was performed on 205 couples who were selec...
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ژورنال
عنوان ژورنال: Kidney and Blood Pressure Research
سال: 2019
ISSN: 1420-4096,1423-0143
DOI: 10.1159/000497487